I’m about to make two statements that will seem contradictory or even hypocritical at first blush. Ready? 1) Videogames are an artform every bit as important, interesting, and culturally relevant as any other medium, such as literature or film. Videogames are not an inherently lesser medium and can (and should) handle any topic with gravitas and grace. 2) I absolutely shudder if I hear about a videogame trying to comment on rape, AIDS, abortion, or other “serious” and deeply personal topics.
See, those things may sound like they are at odds, but there’s one word buried in there that rescues me from accusations of hypocrisy - “inherently.” Videogames are not inherently lesser as a medium - that is to say that they don’t have to be bad at handling certain topics - but the sad fact is that they currently are.
Game developers (and this is especially true in the AAA world, though indies are not exempt) are too caught up in games as toys, games as products, games as nostalgia, games as cash cows, games as collections of mechanics, etc., to honestly and truly examine and explore tough topics with the level of depth and maturity that they deserve. Right now (and again, I stress this is the current - not permanent - state of affairs), videogames excel at excess, at visceral violence, at “badass” and at “epic.” They do not excel at nuance or honesty or sincerity, and these characteristics are essential for those creators who want to comment on the difficult and sensitive issues in society.
So, the short answer to your question? No topic is too sensitive for games to handle. But until developers can see their medium as something other than a paycheck, and tackle these problems with a measure of maturity and heart, they will continue to come off as heavy-handed, incompetent, and offensive. There will come a day when videogames treating serious subject matter will be par for the course, but that day is not today.